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Common Imitrex uses
This medicine is a cerebral vasoconstrictor used to relieve migraine headache attacks as they occur. It will not prevent or reduce the number of attacks you experience.
Before using Imitrex
Some medicines or medical conditions may interact with this medicine. INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. DO NOT TAKE THIS MEDICINE if you are also taking monoamine oxidase inhibitors (MAOIs). ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are taking ergot alkaloids. Inform your doctor of any other medical conditions, allergies, pregnancy, or breast-feeding. USE OF THIS MEDICINE IS NOT RECOMMENDED if you have a history of chest pain, heart conditions, arrhythmias, high blood pressure, or stroke. Contact your doctor or pharmacist if you have any questions or concerns about taking this medicine.
Imitrex Directions
Follow the directions for using this medicine provided by your doctor. SWALLOW WHOLE. Do not break, crush, or chew before swallowing. IT IS BEST TO TAKE A DOSE OF THIS MEDICINE as soon as you notice symptoms of a migraine attack. Allow 2 hours between taking doses of this medicine. DO NOT TAKE ADDITIONAL DOSES if you do not get a response from the first dose. STORE THIS MEDICINE at room temperature in a tightly-closed container, away from heat and light.
Imitrex Cautions
THIS MEDICINE IS NOT INTENDED to prevent or reduce the number of migraine attacks that you experience. IF YOU HAVE A HEADACHE THAT IS DIFFERENT than your usual migraine attacks, check with your doctor before using this medicine. BEFORE YOU BEGIN USING THIS MEDICINE, give your doctor and pharmacist a list of all prescription and non-prescription medicines that you are using to treat and prevent migraine attacks. DO NOT USE ERGOT-CONTAINING MEDICINES within 24 hours of using this medicine. If you have questions about which medicines contain ergot, ask your doctor or pharmacist. BEFORE USING THIS MEDICINE ALSO TELL YOUR DOCTOR if you have chest pains, heart disease, shortness of breath, irregular heartbeats, high blood pressure, high cholesterol, or diabetes. Also tell your doctor if you smoke, if you have had a heart attack, if you have liver or kidney disease, are post-menopausal, or have had any seizures. Keep your doctor informed if you develop any of these conditions while you are taking this medicine. THIS MEDICINE MAY CAUSE DIZZINESS. Using this medicine alone, with other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks. Ask your doctor or pharmacist if you have questions about which medicines can cause dizziness. FOR WOMEN: IF YOU PLAN ON BECOMING PREGNANT, discuss with your doctor the benefits and risks of using this medicine during pregnancy. Imitrex IS EXCRETED IN BREAST MILK. IF YOU ARE OR WILL BE BREAST-FEEDING while you are using this medicine, check with your doctor or pharmacist to discuss the risks to your baby.
Possible Imitrexside effects
SIDE EFFECTS, that may go away during treatment, include nausea, vomiting, dizziness, drowsiness, or feeling sick. If they continue or are bothersome, check with your doctor. CHECK WITH YOUR DOCTOR BEFORE USING ADDITIONAL DOSES if you experience wheezing; tightness in the jaw, neck, or chest; chest pain; or heart throbbing. CONTACT YOUR DOCTOR IMMEDIATELY AND DO NOT USE ANY MORE OF THIS MEDICINE if you experience shortness of breath, swelling of the eyelids, face, or lips, or develop a skin rash or hives. If you notice other effects not listed above, contact your doctor, nurse, or pharmacist.
Drug interactions
Drug interactions can result in unwanted side effects or prevent a medicine from doing its job. Use our drug interaction checker to find out if your medicines interact with each other.
If you take too much
If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include tremor, chest pain, slowed breathing, and seizures.
Additional information
If this medicine does not stop or decrease the severity of your migraine attack or if your symptoms become worse, check with your doctor. DO NOT SHARE THIS MEDICINE with others for whom it was not prescribed. DO NOT USE THIS MEDICINE for other health conditions. KEEP THIS MEDICINE out of the reach of children and pets. IF USING THIS Imitrex cheap MEDICINE FOR AN EXTENDED PERIOD OF TIME, obtain refills before your supply runs out.
IMITREX)
(sumatriptan succinate)
Tablets
DESCRIPTION
Imitrex tablets contain sumatriptan a selective 5-hydroxytryptamine receptor subtype agonist. Imitrex is used to treat migraine headache attacks once they occur. It is not effective in preventing migraines. Imitrex is not to be used for other types of headaches.
Imitrex tablet for oral administration contains 35, 70, or 140 mg of sumatriptan succinate equivalent to 25, 50, or 100 mg of sumatriptan, respectively. Each buy Imitrex tablet also contains the inactive ingredients croscarmellose sodium, iron oxide (100-mg tablet only), lactose, magnesium stearate, microcrystalline cellulose, and titanium dioxide.
Pharmacokinetics: The mean maximum concentration of Imitrex following oral dosing with 25 mg is 18 ng/mL (range, 7 to 47 ng/mL) and 51 ng/mL (range, 28 to 100 ng/mL) following oral dosing with 100 mg of Imitrex. This compares with a C max of 5 and 16 ng/mL following dosing with a 5- and 20-mg intranasal dose, respectively. The mean C max following a 6-mg subcutaneous injection of Imitrex is 71 ng/mL (range, 49 to 110 ng/mL). The bioavailability is approximately 15%, primarily due to presystemic metabolism and partly due to incomplete absorption. The C max is similar during a migraine attack and during a migraine-free period, but the T max is slightly later during the attack, approximately 2.5 hours compared to 2.0 hours. When given as a single dose, Imitrex displays dose proportionality in its extent of absorption (area under the curve [AUC]) over the dose range of 25 to 200 mg, but the C max after 100 mg is approximately 25% less than expected (based on the 25-mg dose). Food has no significant effect on the bioavailability of Imitrex, but delays the T max slightly (by about 0.5 hours).
Special Populations: Kidney Impairment: The effect of renal impairment on the pharmacokinetics of Imitrex has not been examined, but little clinical effect would be expected as Imitrex is largely metabolized to an inactive substance.
Liver Impairment: The liver plays an important role in the presystemic clearance of orally administered Imitrex. Accordingly, the bioavailability of Imitrex following oral administration may be markedly increased in patients with liver disease. In 1 small study of hepatically impaired patients (n = 8) matched for sex, age, and weight with healthy subjects, the hepatically impaired patients had an approximately 70% increase in AUC and C max and a T max 40 minutes earlier compared to the healthy subjects who took Imitrex.
AGE: The pharmacokinetics of oral Imitrex in the elderly (mean age, 72 years; 2 males and 4 females) and in patients with migraine (mean age, 38 years; 25 males and 155 females) were similar to that in healthy male subjects (mean age, 30 years).
Gender: In a study comparing females to males taking buy Imitrex online , no pharmacokinetic differences were observed between genders for AUC, C max , T max , and half-life.
Race: The systemic clearance and C max of Imitrex were similar in black (n = 34) and Caucasian (n = 38) healthy male subjects.
Drug Interactions: Monoamine Oxidase Inhibitors: Treatment with MAO-A inhibitors generally leads to an increase of Imitrex plasma levels.
Due to gut and hepatic metabolic first-pass effects, the increase of systemic exposure after coadministration of an MAO-A inhibitor with oral Imitrex is greater than after coadministration of the monoamine oxidase inhibitors (MAOI) with subcutaneous Imitrex. In a study of 14 healthy females, pretreatment with an MAO-A inhibitor decreased the clearance of subcutaneous Imitrex. Under the conditions of this experiment, the result was a 2-fold increase in the area under the Imitrex plasma concentration x time curve (AUC), corresponding to a 40% increase in elimination half-life. This interaction was not evident with an MAO-B inhibitor.
A small study evaluating the effect of pretreatment with an MAO-A inhibitor on the bioavailability from a 25-mg oral Imitrex tablet resulted in an approximately 7-fold increase in systemic exposure.
Alcohol: Alcohol consumed 30 minutes prior to Imitrex ingestion had no effect on the pharmacokinetics of buy cheap Imitrex.
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Imitrex
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